This issue pertains to both traditional materials, such as composite filling substances and denture bases, and modern CAD/CAM-derived materials, including milled or 3D-printed products. Differences in composition and production techniques may in several ways have an influence on monomer leaching.

Proper handling and curing are crucial across all material types. Bulk-fill materials, for instance, exhibit increased monomer leaching under inadequate curing conditions. In contrast, industrially produced resin blocks demonstrate significantly lower leaching compared to traditional composites. Notably, reports of adverse effects related to resin-based dental materials in Norway have been low and stable over the past two decades.

It is important to understand the factors that affect monomer leaching to ensure patient safety and material effectiveness in dental applications.

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